Episode 75

On a GLP-1 - You Should be on the Mediterranean Diet Also

Published on: 7th May, 2025

Weight Loss Surgery and Mediterranean Diet to GLP-1 and the Mediterranean Diet

For years, I have guided my weight loss surgery patients toward the Mediterranean diet. Why? Because it’s not only delicious and sustainable, but it’s also backed by decades of science. Now, as GLP-1 medications like Ozempic and Zepbound transform how we approach obesity, the question arises again: what should people eat while on these powerful drugs? The answer, as it turns out, remains the same.

GLP-1 medications have undeniably revolutionized weight loss. These drugs, originally developed for diabetes, have rapidly gained fame for helping individuals shed significant amounts of weight. They work by reducing appetite, slowing stomach emptying, and altering hunger signals in the brain. Many patients simply cannot achieve sustained weight loss with diet alone, and for them, GLP-1 drugs are life-changing.

However, while these medications help people lose weight, they do not address everything. Weight loss is only part of the equation. Nutrition still matters deeply. Without nourishing your body properly, you risk missing out on crucial benefits such as inflammation reduction, cardiovascular protection, and cognitive preservation.

The Mediterranean Diet

This is exactly where the Mediterranean diet shines. For decades, in fact, over 70 years, researchers have studied this dietary pattern. More than 13,000 scientific publications support its benefits. It’s not just about eating "like people in the Mediterranean." Rather, it’s about embracing a carefully studied set of foods, in specific amounts, shown to optimize health outcomes.

For example, the diet emphasizes:

  • Around 9 ounces (250 grams) of fruits daily.
  • Plenty of vegetables and whole grains.
  • Healthy fats, especially from olive oil.
  • Lean proteins, particularly fish and legumes.
  • Limited red meat and alcohol.

Studies Showing the Diet Works For Health

The science is clear. The PREDIMED study demonstrated significant reductions in cardiovascular events among followers of this diet. The EPIC studies have shown lower overall mortality, reduced cancer risk, and enhanced longevity. Furthermore, other research consistently links the Mediterranean diet to better insulin sensitivity, lower diabetes incidence, and reduced Alzheimer’s risk.

So, how does this all connect to GLP-1 medications? Simple. If you are using GLP-1 drugs, you are already taking control of your weight. Why stop there? Combining these medications with a Mediterranean diet maximizes your health benefits. While the drugs help you eat less and lose weight, the diet ensures that what you do eat is packed with nutrition, anti-inflammatory compounds, and essential nutrients.

Examples of the Diet in Real Life

In practical terms, adopting this diet does not have to be complicated. For breakfast, try Greek yogurt topped with fresh berries, or overnight oats with fruit and nuts. For lunch, enjoy a salad filled with leafy greens, chickpeas, avocado, and stone fruits, drizzled with olive oil and lemon. For dinner, think grilled salmon or chicken, paired with quinoa or farro and plenty of colorful vegetables.

Ultimately, GLP-1 drugs and the Mediterranean diet are not competing solutions — they are complementary tools. Together, they support not just weight loss, but whole-body health.

If you are on a GLP-1 medication, remember this: losing weight is important, but being healthy while losing weight is essential. The Mediterranean diet remains the gold standard, helping you do both.

Don't forget your vitamins

If you are on a GLP-1 medication, please take a daily multivitamin. There are plenty of them out there, but you need these daily. Especially the B-complex. I like this one from YouTheory.

Transcript
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>> Dr. Terry Simpson: Foreign.

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You've probably heard about GLP1 medications

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like ozempic and Zeppelin. Initially developed for

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diabetes, they have become significant

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for weight loss. Here's an

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essential truth. These medications are

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necessary for many people because people

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can't sustain weight loss through

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diet alone. In spite of what many

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gym bros will tell you today,

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we're going to tell you how you should eat if

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you're on a GLP1 medication. Now,

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we've covered some of this ground before, but

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never with such a verb.

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I am your Chief Medical Explanationist, Dr. Terry

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Simpson, and this is for

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Q4Q where we make sense of

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the madness, bust a few myths, and teach you a little bit

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about food as medicine.

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GLP1 medications have revolutionized weight

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loss and they will continue to do so.

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However, a critical question often remains.

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What should people eat while they're on these

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medications? Unfortunately, we have clear evidence based

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answers. While GLP1 drugs might help

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manage weight effectively, good nutrition

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is vital, especially when

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you have perceptibly inability to eat

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as much as you did before. Medication

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alone while delivering weight loss doesn't deliver

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optimal health, but combining it with a nutritious

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diet amplifies the benefits and ensures

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overall wellness. Weight loss is important,

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but we also aim to be healthy in the process.

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We discovered this during the time when I was doing weight loss

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surgery. It seems that I would look around

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and say, what is the optimal diet for people who've

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had weight loss surgery? And there were

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thousands of answers. Many weight loss surgeons had their

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own versions of diets and recipes,

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often falling into some low carb or keto

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ionosphere. And then I went to

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culinary medicine school and spent

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hours researching the various diets. Not

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from a perspective of, uh, the books that you

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find in a bookstore, the popular stuff you would

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see online. But what does the evidence

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actually show us? And it became

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very clear that the Mediterranean diet remains

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unmatched in providing long term health benefits.

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The diet, which is rich in fruits, vegetables, whole grains,

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legumes, lean proteins, healthy fats like olive oil,

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and even a little moderate wine consumption,

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enhances the benefits of my weight loss

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surgery patients. And now we're seeing

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the benefits in those patients on GLP1

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medications. We've talked extensively about the

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Mediterranean diet on 4Q and I invite you to go back and listen

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to those where we've highlighted its structured

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nutritional guidelines, such as consuming 9 ounces

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or 250 grams of fruits and vegetables daily,

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limiting red meat and alcohol, and prioritizing

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monounsaturated fatty acids.

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Numerous studies have shown that the Mediterranean diet reduces

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inflammation, decreases cardiovascular

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risks, improves cognitive function

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and lowers diabetes risks. For instance,

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there was a prediment study demonstrating the

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significant reduction in cardiovascular events,

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the Lyon Heart Study, which showed that people who had

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a heart attack their first heart attack had a

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reduction of almost 75% about getting a

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second heart attack by following a, um, Mediterranean diet.

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There was something called the EPIC study, which showed that there

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was a decrease in overall mortality, improved

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cancer outcomes and enhanced longevity among

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those who had the Mediterranean diet. Research

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has consistently shown improved cognitive function, reduced

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Alzheimer's risk, and associated with

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better insulin sensitivity and diabetes

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control. So you're probably wondering, where do

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I start? And there are some practical

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examples. Here's how you can incorporate a

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Mediterranean diet. For example, breakfast. You might consider

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some Greek yogurt toppled with fresh berries or one

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of my favorites, overnight oats with some mixed berries and

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fruits. You don't need too much of this, but

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not only will you feel better and have a good start to your day, but

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increasing fiber allows your guts to

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feel good and thank you. Lunch could be a colorful salad

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of leafy greens, chickpeas, tuna, avocado

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and stone fruits like peaches or nectarines

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drizzled with olive oil and some lemon juice.

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Dinner might be something simple like grilled salmon or chicken

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with quinoa or farro, along with some steamed or

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roasted vegetables like broccoli, asparagus or

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zucchini. Okay, one of those I actually

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like. These examples make adopting the

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Mediterranean lifestyle manageable and delicious. When I

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say one of those I might actually like, it's true there are many

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vegetables I don't like. Fortunately, there

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are plenty of vegetables out there, and that means

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that you aren't limited to what you find in the

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Mediterranean. For example, you might think rice is

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Mediterranean. It's not. You might think tomatoes are

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Mediterranean. Clearly it's not. But those are

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fruits and vegetables and whole grains that are beneficial

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in long term studies.

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So while GLP1 medications like Ozempic

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and Zeppelin effectively manage and treat

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obesity, pairing them with a Mediterranean

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diet optimizes your health, amplifying

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anti inflammatory and cardioprotective and anti cancer

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effects. With over 70 years of research and

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more than 13,000 scientific

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publications supporting it, the Mediterranean diet

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isn't just about regional cuisine.

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It's a scientifically validated approach

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detailing specific foods and amounts to

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boost overall health. So you won't just be

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losing weight, but you'll actively enhance your

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overall health. GLP1 drugs have

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revolutionized weight management, but true

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health emerges when combined with a nutritious,

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balanced diet. Not another protein bar,

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not another protein shake. And the Mediterranean diet, uh,

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clearly stands out for long term health improvements.

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Remember, it's not just about shedding pounds, it's about

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becoming healthier in the process.

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And don't forget to add a multivitamin

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to your list of things. If you're taking GLP1

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drugs, it is essential to be able to get

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adequate amounts of nutrition. And if you're

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not, Mediterranean diet. And adding a

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multivitamin is a just about, uh, belt

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and suspenders approach. Thanks

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for joining me on 4Q. Don't forget

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to subscribe, share and stay hungry for knowledge that

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is. This podcast has been

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researched and written by me, Dr. Terri

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Simpson. And while I am a physician, I am not your

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physician. Before making any changes, especially

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when on, um, the GLP1 drug, please check with your

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physician and a registered dietitian.

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Not with a chiropractor, not with an eastern trained

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physician. We were distributed by our friends at

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Simpler media and the Pod God. My good friend,

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Mr. Evo Terre

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until next week. Thanks for listening, thanks for

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subscribing, and thanks for saying the kind words on all

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of those different places. You'll find me in my podcast.

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Until then, have a Good week. I'm Dr.

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Simpson. Goodbye,

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de Evo.

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I discovered overnight oats with

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a little bit of apple sauce or apple

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juice added to it. It's

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delicious. You ought to give it a try sometime.

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I am on board the overnight Oats

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Ch train. Um, but I hadn't considered putting other

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stuff into it. Experimentation

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shall ensue.

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About the Podcast

Fork U with Dr. Terry Simpson
Learn more about what you put in your mouth.
Fork U(niversity)
Not everything you put in your mouth is good for you.

There’s a lot of medical information thrown around out there. How are you to know what information you can trust, and what’s just plain old quackery? You can’t rely on your own “google fu”. You can’t count on quality medical advice from Facebook. You need a doctor in your corner.

On each episode of Your Doctor’s Orders, Dr. Terry Simpson will cut through the clutter and noise that always seems to follow the latest medical news. He has the unique perspective of a surgeon who has spent years doing molecular virology research and as a skeptic with academic credentials. He’ll help you develop the critical thinking skills so you can recognize evidence-based medicine, busting myths along the way.

The most common medical myths are often disguised as seemingly harmless “food as medicine”. By offering their own brand of medicine via foods, These hucksters are trying to practice medicine without a license. And though they’ll claim “nutrition is not taught in medical schools”, it turns out that’s a myth too. In fact, there’s an entire medical subspecialty called Culinary Medicine, and Dr. Simpson is certified as a Culinary Medicine Specialist.

Where today's nutritional advice is the realm of hucksters, Dr. Simpson is taking it back to the realm of science.

About your host

Profile picture for Terry Simpson

Terry Simpson

Dr. Terry Simpson received his undergraduate, graduate, and medical degrees from the University of Chicago where he spent several years in the Kovler Viral Oncology laboratories doing genetic engineering. Until he found he liked people more than petri dishes. Dr. Simpson, a weight loss surgeon is an advocate of culinary medicine, he believes teaching people to improve their health through their food and in their kitchen. On the other side of the world, he has been a leading advocate of changing health care to make it more "relationship based," and his efforts awarded his team the Malcolm Baldrige award for healthcare in 2018 and 2011 for the NUKA system of care in Alaska and in 2013 Dr Simpson won the National Indian Health Board Area Impact Award. A frequent contributor to media outlets discussing health related topics and advances in medicine, he is also a proud dad, husband, author, cook, and surgeon “in that order.”